Affordable Access

deepdyve-link
Publisher Website

MUC1 drives epithelial–mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter

Authors
  • Gnemmi, Viviane
  • Bouillez, Audrey
  • Gaudelot, Kelly
  • Hémon, Brigitte
  • Ringot, Bélinda
  • Pottier, Nicolas
  • Glowacki, François
  • Villers, Arnauld
  • Vindrieux, David
  • Cauffiez, Christelle
  • Seuningen, Isabelle Van
  • Bernard, David
  • Leroy, Xavier
  • Aubert, Sébastien
  • Perrais, Michaël1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 7, 16, 17, 7, 18, 19
  • 1 Institut National de la Santé et de la Recherche Médicale (Inserm)
  • 2 UMR837
  • 3 Equipe 5 “Mucines, différenciation et cancérogenèse épithéliales”
  • 4 Jean-Pierre Aubert Research Center
  • 5 Institute of Pathology
  • 6 Centre de Biologie-Pathologie
  • 7 CHRU de Lille
  • 8 Faculté de Médecine Henri-Warembourg
  • 9 Université de Lille 2
  • 10 EA4483
  • 11 Department of Biochemistry and Molecular Biology
  • 12 Faculté de Médecine
  • 13 Pôle Recherche
  • 14 Department of Nephrology
  • 15 Hôpital Huriez
  • 16 Department of Urology
  • 17 Hopital Huriez
  • 18 UMR CNRS 5286/INSERM 1052
  • 19 Centre de Recherche en Cancérologie de Lyon
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 01, 2013
Accepted Date
Dec 20, 2013
Volume
346
Issue
2
Pages
225–236
Identifiers
DOI: 10.1016/j.canlet.2013.12.029
Source
Elsevier
Keywords
License
Unknown

Abstract

MUC1 is overexpressed in human carcinomas. The transcription factor SNAIL can activate epithelial–mesenchymal transition (EMT) in cancer cells. In this study, in renal carcinoma, we demonstrate that (i) MUC1 and SNAIL were overexpressed in human sarcomatoid carcinomas, (ii) SNAIL increased indirectly MUC1 expression, (iii) MUC1 overexpression induced EMT, (iv) MUC1 C-terminal domain (MUC1-C) and β-catenin increased SNAIL transcriptional activity by interaction with its promoter and (v) blocking MUC1-C nuclear localization decreased Wnt/β-catenin signaling pathway activation and SNAIL expression. Altogether, our findings demonstrate that MUC1 is an actor in EMT and appears as a new therapeutic target.

Report this publication

Statistics

Seen <100 times