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Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation.

Authors
  • Zhang, Rui-Xin
  • Wang, Linbo
  • Liu, Bing
  • Qiao, Jian-Tian
  • Ren, Ke
  • Berman, Brian M
  • Lao, Lixing
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Jun 28, 2005
Volume
1048
Issue
1-2
Pages
235–240
Identifiers
PMID: 15922310
Source
Medline
License
Unknown

Abstract

Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia.

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