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mTOR signaling in stem and progenitor cells.

Authors
  • Meng, Delong1, 2, 3
  • Frank, Anderson R1, 2, 3
  • Jewell, Jenna L4, 2, 3
  • 1 Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • 2 Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • 3 Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • 4 Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA [email protected]
Type
Published Article
Journal
Development
Publisher
The Company of Biologists
Publication Date
Jan 08, 2018
Volume
145
Issue
1
Identifiers
DOI: 10.1242/dev.152595
PMID: 29311260
Source
Medline
Keywords
License
Unknown

Abstract

The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases, such as cancer, and in diabetes and ageing. Recently, however, new studies have demonstrated important roles for mTOR in promoting the differentiation of adult stem cells, driving the growth and proliferation of stem and progenitor cells, and dictating the differentiation program of multipotent stem cell populations. Here, we review these advances, providing an overview of mTOR signaling and its role in murine and human stem and progenitor cells.

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