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mTOR Signaling in Metabolism and Cancer

Authors
  • Huang, Shile1, 2
  • 1 ; Tel.: +1-318-675-7759
  • 2 Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130-3932, USA
Type
Published Article
Journal
Cells
Publisher
MDPI AG
Publication Date
Oct 13, 2020
Volume
9
Issue
10
Identifiers
DOI: 10.3390/cells9102278
PMID: 33065976
PMCID: PMC7601420
Source
PubMed Central
Keywords
License
Green

Abstract

The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting the mTOR pathway is a promising strategy to fight against certain human diseases.

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