The results illustrate the power of GFP-technology combined with FRET-FLIM imaging in the study of the interaction of signalling components in living cells, here providing evidence for a direct physical interaction between mTOR and Rheb and between mTOR and raptor in living cells for the first time.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/23311891