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mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging.

Authors
  • Yadav, Rahul B
  • Burgos, Pierre
  • Parker, Anthony W
  • Iadevaia, Valentina
  • Proud, Christopher G
  • Allen, Rodger A
  • O'Connell, James P
  • Jeshtadi, Ananya
  • Stubbs, Christopher D
  • Botchway, Stanley W
Type
Published Article
Journal
BMC Cell Biology
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2013
Volume
14
Pages
3–3
Identifiers
DOI: 10.1186/1471-2121-14-3
PMID: 23311891
Source
Medline
License
Unknown

Abstract

The results illustrate the power of GFP-technology combined with FRET-FLIM imaging in the study of the interaction of signalling components in living cells, here providing evidence for a direct physical interaction between mTOR and Rheb and between mTOR and raptor in living cells for the first time.

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