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mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution

Authors
  • Weber, Christopher M.1, 1
  • Hafner, Antonina1
  • Kirkland, Jacob G.1, 1, 2
  • Braun, Simon M. G.1, 1, 3
  • Stanton, Benjamin Z.4, 5, 6
  • Boettiger, Alistair N.1
  • Crabtree, Gerald R.1, 1, 7
  • 1 Stanford University School of Medicine, Stanford, CA, USA , Stanford (United States)
  • 2 Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA , Oklahoma City (United States)
  • 3 University of Geneva, Department of Genetic Medicine, Geneva, Switzerland , Geneva (Switzerland)
  • 4 Nationwide Children’s Hospital, Center for Childhood Cancer and Blood Diseases, Columbus, OH, USA , Columbus (United States)
  • 5 Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA , Columbus (United States)
  • 6 The Ohio State University College of Medicine, Columbus, OH, USA , Columbus (United States)
  • 7 Howard Hughes Medical Institute, Chevy Chase, MD, USA , Chevy Chase (United States)
Type
Published Article
Journal
Nature Structural & Molecular Biology
Publisher
Springer Nature
Publication Date
Jun 11, 2021
Volume
28
Issue
6
Pages
501–511
Identifiers
DOI: 10.1038/s41594-021-00604-7
Source
Springer Nature
Disciplines
  • article
License
Yellow

Abstract

Chemical genetic dissection of the SWI/SNF–Polycomb axis in mouse stem cells identifies an unexpected role for mSWI/SNF in repression, providing mechanistic insight into the dynamic ‘tug of war’ between transcriptional activation and repression.

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