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MRP8/14 induces autophagy to eliminate intracellular Mycobacterium bovis BCG.

Authors
  • Wang, Jinli1
  • Huang, Chunyu2
  • Wu, Minhao3
  • Zhong, Qiu4
  • Yang, Kun3
  • Li, Miao3
  • Zhan, Xiaoxia3
  • Wen, Jinsheng5
  • Zhou, Lin6
  • Huang, Xi7
  • 1 Department of Immunology, Institute of Tuberculosis Control, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China; Department of Laboratory Medicine, Guangzhou First Municipal People's Hospital, Affiliated Hospital of Guangzhou Medical University, Guangzhou 510500, China. , (China)
  • 2 Department of Immunology, Institute of Tuberculosis Control, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China; Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China. , (China)
  • 3 Department of Immunology, Institute of Tuberculosis Control, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China. , (China)
  • 4 Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, China. , (China)
  • 5 Department of Microbiology and Immunology, Wenzhou Medical University, Wenzhou 325035, China. , (China)
  • 6 Center for Tuberculosis Control of Guangdong Province, Guangzhou 510630, China. Electronic address: [email protected] , (China)
  • 7 Department of Immunology, Institute of Tuberculosis Control, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China; Department of Microbiology and Immunology, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
The Journal of infection
Publication Date
April 2015
Volume
70
Issue
4
Pages
415–426
Identifiers
DOI: 10.1016/j.jinf.2014.09.013
PMID: 25312864
Source
Medline
Keywords
License
Unknown

Abstract

The present study revealed a novel role of MRP8/14 in the autophagy-mediated elimination of intracellular BCG by promoting ROS generation, which may provide a promising therapeutic target for tuberculosis and other intracellular bacterial infectious diseases.

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