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mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription.

Authors
Type
Published Article
Journal
Current Opinion in Cell Biology
0955-0674
Publisher
Elsevier
Publication Date
Volume
11
Issue
3
Pages
352–357
Identifiers
PMID: 10395555
Source
Medline
License
Unknown

Abstract

Eukaryotic mRNA precursors are processed at their 3' ends by a coupled cleavage/polyadenylation reaction. In recent years, most of the factors involved in 3'-end processing have been identified and evidence has been presented for the coupling of mRNA 3'-end formation to capping, splicing and transcription. These links are important for the quality control of the mRNA during synthesis.

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