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Mouse visual cortex contains a region of enhanced spatial resolution.

  • van Beest, Enny H
  • Mukherjee, Sreedeep
  • Kirchberger, Lisa
  • Schnabel, Ulf H
  • van der Togt, Chris
  • Teeuwen, Rob R M
  • Barsegyan, Areg
  • Meyer, Arne F
  • Poort, Jasper
  • Roelfsema, Pieter R
  • Self, Matthew W
Publication Date
Jun 29, 2021
Apollo - University of Cambridge Repository
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The representation of space in mouse visual cortex was thought to be relatively uniform. Here we reveal, using population receptive-field (pRF) mapping techniques, that mouse visual cortex contains a region in which pRFs are considerably smaller. This region, the "focea," represents a location in space in front of, and slightly above, the mouse. Using two-photon imaging we show that the smaller pRFs are due to lower scatter of receptive-fields at the focea and an over-representation of binocular regions of space. We show that receptive-fields of single-neurons in areas LM and AL are smaller at the focea and that mice have improved visual resolution in this region of space. Furthermore, freely moving mice make compensatory eye-movements to hold this region in front of them. Our results indicate that mice have spatial biases in their visual processing, a finding that has important implications for the use of the mouse model of vision.

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