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Mouse Systems Genetics as a Prelude to Precision Medicine.

Authors
  • Li, Hao1
  • Auwerx, Johan2
  • 1 Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland. , (Switzerland)
  • 2 Laboratory of Integrative Systems Physiology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland. Electronic address: [email protected] , (Switzerland)
Type
Published Article
Journal
Trends in Genetics
Publisher
Elsevier
Publication Date
Apr 01, 2020
Volume
36
Issue
4
Pages
259–272
Identifiers
DOI: 10.1016/j.tig.2020.01.004
PMID: 32037011
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Mouse models have been instrumental in understanding human disease biology and proposing possible new treatments. The precise control of the environment and genetic composition of mice allows more rigorous observations, but limits the generalizability and translatability of the results into human applications. In the era of precision medicine, strategies using mouse models have to be revisited to effectively emulate human populations. Systems genetics is one promising paradigm that may promote the transition to novel precision medicine strategies. Here, we review the state-of-the-art resources and discuss how mouse systems genetics helps to understand human diseases and to advance the development of precision medicine, with an emphasis on the existing resources and strategies. Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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