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Motion-robust sub-millimeter isotropic diffusion imaging through motion corrected generalized slice dithered enhanced resolution (MC-gSlider) acquisition.

Authors
  • Wang, Fuyixue1, 2
  • Bilgic, Berkin1
  • Dong, Zijing3
  • Manhard, Mary Kate1
  • Ohringer, Ned1
  • Zhao, Bo1
  • Haskell, Melissa1, 4
  • Cauley, Stephen F1
  • Fan, Qiuyun1
  • Witzel, Thomas1, 2
  • Adalsteinsson, Elfar2, 5, 6
  • Wald, Lawrence L1, 2
  • Setsompop, Kawin1, 2
  • 1 A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts.
  • 2 Harvard-MIT Health Sciences and Technology, MIT, Cambridge, Massachusetts.
  • 3 Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China. , (China)
  • 4 Department of Biophysics, Harvard University, Cambridge, Massachusetts.
  • 5 Department of Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts.
  • 6 Institute for Medical Engineering and Science, MIT, Cambridge, Massachusetts.
Type
Published Article
Journal
Magnetic Resonance in Medicine
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2018
Volume
80
Issue
5
Pages
1891–1906
Identifiers
DOI: 10.1002/mrm.27196
PMID: 29607548
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To develop an efficient MR technique for ultra-high resolution diffusion MRI (dMRI) in the presence of motion. gSlider is an SNR-efficient high-resolution dMRI acquisition technique. However, subject motion is inevitable during a prolonged scan for high spatial resolution, leading to potential image artifacts and blurring. In this study, an integrated technique termed Motion Corrected gSlider (MC-gSlider) is proposed to obtain high-quality, high-resolution dMRI in the presence of large in-plane and through-plane motion. A motion-aware reconstruction with spatially adaptive regularization is developed to optimize the conditioning of the image reconstruction under difficult through-plane motion cases. In addition, an approach for intra-volume motion estimation and correction is proposed to achieve motion correction at high temporal resolution. Theoretical SNR and resolution analysis validated the efficiency of MC-gSlider with regularization, and aided in selection of reconstruction parameters. Simulations and in vivo experiments further demonstrated the ability of MC-gSlider to mitigate motion artifacts and recover detailed brain structures for dMRI at 860 μm isotropic resolution in the presence of motion with various ranges. MC-gSlider provides motion-robust, high-resolution dMRI with a temporal motion correction sensitivity of 2 s, allowing for the recovery of fine detailed brain structures in the presence of large subject movements. © 2018 International Society for Magnetic Resonance in Medicine.

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