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Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging

Authors
  • Scupakova, Klara(*)
  • Dewez, Frédéric(*)
  • Walch, Axel
  • Heeren, Ron M.A
  • Balluff, Benjamin
Publication Date
Jul 15, 2020
Source
ORBi
Keywords
Language
English
License
Green
External links

Abstract

The large‐scale and label‐free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single‐cell‐specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.

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