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[Morphological signs of mitochondrial cytopathy in skeletal muscles and micro-vessel walls in a patient with cerebral artery dissection associated with MELAS syndrome].

Authors
  • Sakharova, A V
  • Kalashnikova, L A
  • Chaĭkovskaia, R P
  • Mir-Kasimov, M F
  • Nazarova, M A
  • Pykhtina, T N
  • Dobrynina, L A
  • Patrusheva, N L
  • Patrushev, L I
  • Protskiĭ, S V
Type
Published Article
Journal
Arkhiv patologii
Publication Date
Jan 01, 2012
Volume
74
Issue
2
Pages
51–56
Identifiers
PMID: 22880419
Source
Medline
License
Unknown

Abstract

Skin and muscles biopsy specimens of a patient harboring A3243G mutation in mitochondrial DNA, with dissection of internal carotid and vertebral arteries, associated with MELAS were studied using histochemical and electron-microscopy techniques. Ragged red fibers, regional variability of SDH histochemical reaction, two types of morphologically atypical mitochondria and their aggregation were found in muscle. There was correlation between SDH histochemical staining and number of mitochondria revealed by electron microscopy in muscle tissue. Similar mitochondrial abnormality, their distribution and cell lesions followed by extra-cellular matrix mineralization were found in the blood vessel walls. In line with generalization of cytopathy process caused by gene mutation it can be supposed that changes found in skin and muscle microvessels also exist in large cerebral vessels causing the vessel wall "weakness", predisposing them to dissection.

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