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Morphological, histochemical, and interstitial pressure changes in the tibialis anterior muscle before and after aortofemoral bypass in patients with peripheral arterial occlusive disease

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BioMed Central
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PMC
Keywords
  • Research Article
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  • Biology
  • Chemistry
  • Medicine

Abstract

1471-2474-3-8.fm ral BioMed CentBMC Musculoskeletal Disorders BMC Musculoskeletal Disorders 2002, 3Research article Morphological, histochemical, and interstitial pressure changes in the tibialis anterior muscle before and after aortofemoral bypass in patients with peripheral arterial occlusive disease Maria Albani*1, Angelos Megalopoulos2, Dimitris Kiskinis2, Sotirios A Parashos4, Nikolaos Grigoriadis3 and Olympia Guiba-Tziampiri1 Address: 1Department of Physiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece, 2Dept of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece, 3Dept of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece and 4Minneapolis Clinic of Neurology, 6330 France Avenue, Edina, Minnesota, 55435, U.S.A E-mail: Maria Albani* - [email protected]; Angelos Megalopoulos - [email protected]; Dimitris Kiskinis - [email protected]; Sotirios A Parashos - [email protected]; Nikolaos Grigoriadis - [email protected]; Olympia Guiba-Tziampiri - [email protected] *Corresponding author Abstract Background: Morphological and electrophysiological studies of ischemic muscles in peripheral arterial disease disclosed evidence of denervation and fibre atrophy. The purpose of the present study is to describe morphological changes in ischemic muscles before and after reperfusion surgery in patients with peripheral occlusive arterial disease, and to provide an insight into the effect of reperfusion on the histochemistry of the reperfused muscle. Methods: Muscle biopsies were obtained from the tibialis anterior of 9 patients with chronic peripheral arterial occlusive disease of the lower extremities, before and after aortofemoral bypass, in order to evaluate the extent and type of muscle fibre changes during ischemia and after revascularization. Fibre type content and muscle fibre areas were quantified using standard histological and histochemical methods and

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