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Morphological and biochemical study of cytoskeletal changes in cultured cells after extracellular application of Clostridium novyi alpha-toxin.

Authors
  • Oksche, A
  • Nakov, R
  • Habermann, E
Type
Published Article
Journal
Infection and immunity
Publication Date
Jul 01, 1992
Volume
60
Issue
7
Pages
3002–3006
Identifiers
PMID: 1612767
Source
Medline
License
Unknown

Abstract

Clostridium novyi alpha-toxin caused retraction and rounding of cultured endothelial cells from porcine pulmonary arteries; nevertheless, the endothelial cells firmly adhered to their supports. F-actin stained with fluorescein-labeled phalloidin was condensed around the nucleus, whereas intermediate filaments and microtubules appeared unchanged. The content of F-actin and myosin was decreased, but that of G-actin or vimentin was not. A predominant role of the microfilament system in C. novyi alpha-toxin cytopathic action is suggested.

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