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Morphologic effects of thio-TEPA on mammalian urothelium. Changes in abnormal cells.

Authors
Type
Published Article
Journal
Acta Cytologica
0001-5547
Publisher
S. Karger AG
Publication Date
Volume
22
Issue
6
Pages
550–554
Identifiers
PMID: 104512
Source
Medline

Abstract

Morphologic changes induced by thio-TEPA were examined in animals with chemically induced neoplasms. Both toxic and metabolic effects were documented. Degeneration, vacuolization and increased exfoliation (toxic) were most prominent, occurred within 48 hours of exposure, and tended to subside after removal of the drug. Nuclear changes (metabolic) were rare and occurred late. Neither toxic nor metabolic effects were specific for thio-TEPA: both could be detected in control animals receiving saline. The metabolic effects of thio-TEPA are not sufficiently widespread to prevent tumor growth.

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