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Morpholinium Glycolate: A Reusable Ionic Liquid Catalyst for the Eco-friendly Synthesis of Dihydropyrano[2,3-c]pyrazol-5-carbonitriles

Authors
  • Syed Abed
  • Mohd Akmal Shaikh
  • Nawaz Ali
  • Mazahar Farooqui
Type
Published Article
Journal
Chemical Science International Journal
Publisher
Sciencedomain International
Publication Date
Oct 21, 2016
Volume
17
Issue
2
Pages
1–8
Identifiers
DOI: 10.9734/CSJI/2016/29519
Source
MyScienceWork
License
Green

Abstract

Morpholinium glycolate was found to be highly potent and reusable ionic liquid as a catalyst for the synthesis of dihydropyrano[2,3-c]pyrazol-5-carbonitriles via a one-pot multicomponent condensation reaction of aryl aldehydes with ethyl acetoacetate, hydrazine hydrate, and malononitrile in an aqueous medium at room temperature. The key advantage of this present protocol is an economical, excellent yield, shorter reaction time, easy work-up, no chromatographic purification and the catalyst can be effortlessly recovered and reused in several runs.

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