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Morphine and morphine-glucuronide concentrations in plasma and CSF during long-term administration of oral morphine.

Authors
  • van Dongen, R T
  • Crul, B J
  • Koopman-Kimenai, P M
  • Vree, T B
Type
Published Article
Journal
British journal of clinical pharmacology
Publication Date
Sep 01, 1994
Volume
38
Issue
3
Pages
271–273
Identifiers
PMID: 7826830
Source
Medline
License
Unknown

Abstract

Concentrations of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were measured by h.p.l.c. in plasma and cerebrospinal fluid (CSF) samples from 16 patients with cancer receiving oral (controlled-release) morphine. There was a close correlation between plasma and CSF morphine concentrations (r = 0.94, P = 0.0001) and both correlated with drug dosage (r = 0.61, P = 0.013 and r = 0.74, P = 0.0001, respectively). M3G and M6G in plasma and CSF were correlated (r = 0.81 and r = 0.82, both P = 0.0001). No relationship was apparent between M plus M6G concentrations in the CSF and pain scores.

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