Affordable Access

deepdyve-link
Publisher Website

Moonlighting activity of the epigenetic machinery restrains infection

Authors
  • Gutierrez, Claude1
  • Boudehen, Yves‐Marie1
  • Neyrolles, Olivier1
  • 1 CNRS, UPS, France , (France)
Type
Published Article
Journal
The EMBO Journal
Publisher
EMBO
Publication Date
Jan 04, 2018
Volume
37
Issue
2
Pages
161–163
Identifiers
DOI: 10.15252/embj.201798679
PMID: 29301860
PMCID: PMC5771391
Source
PubMed Central
Keywords
License
Unknown
External links

Abstract

Intracellular bacterial pathogens have evolved a range of mechanisms, including manipulation of the host cell epigenetic machinery and host cell gene expression rewiring, to parasitize and thrive inside host phagocytes. A new study in The EMBO Journal (Yaseen et al , 2018 ) reports that, conversely, host macrophages can use epigenetic modulators to modify the cell surface of invading pathogens and counteract infection. This study opens new avenues to better understand host–pathogen interactions and to develop novel, more effective antimicrobial strategies.

Report this publication

Statistics

Seen <100 times