Rodents and their ectoparasites were studied inside and outside houses in the newly settled areas, east of lakes, Ismailia Governorate, Egypt. Forty traps per month in each of the two sides were used for collecting rodent during 2009. From 221 rodent were collected from inside houses; Mus musculus N=115 (52.04%), Rattus rattus. frugivorous N=54 (24.43%), R. r. alexandrinus N=40 (18.10%) and R. norvegicus N=12 (5.43%). From 177 rodent were collected from outside houses; M musculus N=4 (2.3%), R. r. frugivorous N=29 (16.43%), R. r. alexandrinus N=37 (20.9%), R. norvegicus N=36 (20.3%), Gerbillus pyramidum N= 67 (37.9%) and Jaculus jaculus N=4 (2.3%). Total ectoparasites per rat inside houses were 765 (3.46 E/Rat) which were classified as fleas, N=464 (2.11 F/R); lice N=150 (0.68 L/R) and mites N=151 (0 68 M/R). From outside house, total ectoparasites per rat were 984 (5.5 E/R) which were classified as fleas, N=410(2.31 F/R); lice N=100 (0.56 L/R), mites N=400 (2.23 M/R) and ticks, N=74 (0.42 T/R). From indoors two fleas species were recorded (Xenopsylla cheopis and Ctenopsyllus segnis); one species of lice (Polyplax spinulosa) and four species of mites (Laelaps nuttall, Ornithonyssus bacoti, Dermanyssus gallinae and Eulaelaps stabularis). The outdoors ectoparasites were; six fleas species (X. cheopis, X. ramesis, Pulex irritans, C. segnis, Stenoponia tripectinata and Nosopsylla sinaiensis); one lice species (P. spinulosa); Six mites species (L. nuttalli, O. bacoti, D. gallinae, E. stabularis, Haemogamnasus pontiger and Hirstionyssus isabellinus) and immature stages of two ticks species (Rhipicephalus sp. and Hyalomma sp.). Most of these ectoparasites were recorded infesting G. pyramidum.