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Monte Carlo (MC) study of dose distribution and Cherenkov imaging in total skin electron therapy (TSET) with TOPAS

Authors
  • Zhong, Weili1
  • Ong, Yi Hong1
  • Zhu, Timothy1
  • 1 Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA USA, 19050
Type
Published Article
Journal
Proceedings of SPIE--the International Society for Optical Engineering
Publication Date
Mar 12, 2021
Volume
11628
Identifiers
DOI: 10.1117/12.2583397
PMID: 34083861
PMCID: PMC8171265
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Malignant tissues can be effectively treated by Total Skin Electron Therapy (TSET) over the entire body surface using 6 MeV electron beams. During the radiation treatment, Cherenkov photons are emitted from the patient’s skin, and can potentially be used for in-vivo imaging of the radiation dose distribution. A Monte Carlo (MC) simulation toolkit TOPAS is used to study the generation and propagation of Cherenkov photons that are generated from the interaction of electron radiation with human tissues, and to understand the relationship between the dose distributions and the Cherenkov photon distributions. Validation of MC simulations with experiments are performed at 100 SSD and 500 SSD, and simulations of a patient phantom in realistic clinical treatment setups have been done. These simulations with TOPAS show that the emitted Cherenkov distributions at phantom surfaces closely follow their corresponding dose distributions.

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