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A Monte Carlo analysis of peritoneal antimicrobial pharmacokinetics.

Authors
  • Hota, Sanjukta
  • Crooke, Philip
  • Hotchkiss, John
Type
Published Article
Journal
Advances in experimental medicine and biology
Publication Date
Jan 01, 2011
Volume
696
Pages
401–410
Identifiers
DOI: 10.1007/978-1-4419-7046-6_40
PMID: 21431580
Source
Medline
License
Unknown

Abstract

Peritoneal dialysis-associated peritonitis (PDAP) can be treated using very different regimens of antimicrobial administration, regimens that result in different pharmacokinetic outcomes and systemic exposure levels. Currently, there is no population-level pharmacokinetic framework germane to the treatment of PDAP. We coupled a differential-equation-based model of antimicrobial kinetics to a Monte Carlo simulation framework, and conducted "in silico" clinical trials to explore the anticipated effects of different antimicrobial dosing regimens on relevant pharmacokinetic parameters (AUC/MIC and time greater than 5 ×MIC) and the level of systemic exposure.

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