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Monocyte defect causes decreased autoMLR in multiple sclerosis patients.

Authors
  • Baxevanis, C N
  • Reclos, G J
  • Arsenis, P
  • Katsiyiannis, A
  • Matikas, N
  • Papamichail, M
Type
Published Article
Journal
Advances in experimental medicine and biology
Publication Date
Jan 01, 1988
Volume
237
Pages
839–842
Identifiers
PMID: 2908171
Source
Medline
License
Unknown

Abstract

We have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (MS) have a defect in stimulating autologous and allogeneic T lymphocytes. This defect was found to correlate with disease activity. We report here that T4+ cells from MS patients proliferate weakly in the autologous mixed lymphocyte reaction (autoMLR). Furthermore, we provide direct proof that the depressed T4+ cell proliferation is due to the monocyte functional (stimulatory) defect.

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