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Monocyte attachment to laminin in diabetes mellitus: The role of ATP.

Authors
Type
Published Article
Journal
Cell Adhesion & Migration
1933-6926
Publisher
Landes Bioscience
Publication Date
Volume
3
Issue
2
Pages
155–159
Identifiers
PMID: 19287210
Source
Medline
License
Unknown

Abstract

Monocyte-extracellular matrix interactions have been implicated in atherosclerosis pathophysiology. Laminin, the main basement membrane protein contains cell binding domains that can be cryptic, presented only after protein modification. In the present study we evaluated monocyte attachment to laminin-1 in the presence of ATP. Monocytes were derived from either healthy volunteers or patients with diabetes mellitus type II. For the estimation of monocyte attachment to laminin the myeloperoxidase assay was used. Monocytes derived from diabetic patients, showed an increased ability to attach to laminin (p = 0.0055). The presence of ATP increased the attachment of control monocytes to laminin (p = 0.0022). On the contrary, the presence of ATP did not affect the attachment of monocytes derived from diabetic patients to laminin. Our results indicate a modified interaction between monocytes and laminin-1 in diabetes mellitus.

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