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[Monoclonal antibodies: technology around the clock for new therapeutic hopes].

Authors
  • Bourel, Dominique1
  • Teillaud, Jean-Luc
  • 1 Département Recherche, Laboratoire Français du Fractionnement et des Biotechnologies, 3, av. des Tropiques, BP 305, Les Ulis, 91958 Courtaboeuf, France. , (France)
Type
Published Article
Journal
Comptes Rendus Biologies
Publisher
Elsevier
Publication Date
Apr 01, 2006
Volume
329
Issue
4
Pages
217–227
Identifiers
PMID: 16644492
Source
Medline
Language
French
License
Unknown

Abstract

Engineering monoclonal antibodies, now widely used in the clinic, has made it possible to develop a new generation of antibodies with optimized functional properties. These antibodies should allow a significant improvement of the treatment of diseases where only few drugs are available, if any. However, the cost of treatments with monoclonal antibodies requires further improvements in production and purification technologies, and raises the question of generic antibodies. The present review summarizes some of the technological past and present challenges in the field.

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