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Monoclonal antibodies specific for murine IgM I. Characterization of antigenic determinants on the four constant domains of the mu heavy chain.

Authors
  • Leptin, M
  • Potash, M J
  • Grützmann, R
  • Heusser, C
  • Shulman, M
  • Köhler, G
  • Melchers, F
Type
Published Article
Journal
European journal of immunology
Publication Date
Jun 01, 1984
Volume
14
Issue
6
Pages
534–542
Identifiers
PMID: 6203757
Source
Medline
License
Unknown

Abstract

Seventeen monoclonal rat antibodies with specificities for mouse mu heavy chain recognize seven distinguishable determinants that are located on the four constant region domains. All determinants are present on secreted, intracellular and membrane bound IgM, and all but two are expressed on isolated mu heavy chain. One antibody, specific for a site in the first constant region domain, recognizes a determinant that is present on IgM of AKR, C3H/HeJ, C57BL/6J, SJL, DBA/2, BALB/c, NZB and CBA/J mouse strains, but not on IgM of A.TH, A/J and A.CA strains of mice.

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