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Monoamine neurotransmitters and metabolites in the cerebrospinal fluid following perinatal asphyxia.

Authors
  • Blennow, M
  • Zeman, J
  • Dahlin, I
  • Lagercrantz, H
Type
Published Article
Journal
Biology of the neonate
Publication Date
Jan 01, 1995
Volume
67
Issue
6
Pages
407–413
Identifiers
PMID: 7578624
Source
Medline
License
Unknown

Abstract

While the release of neurotransmitters is involved in the pathophysiology of brain damage following birth asphyxia, it also plays a role in endogenous defense against such damage. Levels of monoamines and the main cerebral monoamine metabolites in the cerebrospinal fluid (CSF) were measured in asphyxiated and control infants within 24 h after birth. The results indicate an increased turnover of noradrenaline (NA) and dopamine following asphyxia. Furthermore, the NA stores in the brain seem to be exhausted in some cases. We conclude that this increase in catecholamine turnover to some extent explains the clinical symptoms of hypoxic-ischemic encephalopathy and that it may reflect an intrinsic adaptive capacity to perinatal distress.

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