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Monitoring photosensitizer concentration by use of a fiber-optic probe with a small source-detector separation.

Authors
Type
Published Article
Journal
Applied optics
Publication Date
Volume
39
Issue
34
Pages
6508–6514
Identifiers
PMID: 18354664
Source
Medline

Abstract

We present a noninvasive method to track the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescent light with a steady-state fluorescence spectrometer. The ratio of the fluorescent light to the scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source-detector separation; therefore the measurements could be performed through the working channel of an endoscope.

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