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Monitoring CP-93,393 reaction mixtures by flow-injection analysis-mass spectrometry.

Authors
  • Colgan, S T
  • Sharp, T R
  • Hammen, P D
  • Reed, R H
  • Horan, G J
  • Gwiazda, P W
Type
Published Article
Journal
Talanta
Publisher
Elsevier
Publication Date
Jun 01, 1996
Volume
43
Issue
6
Pages
851–857
Identifiers
PMID: 18966555
Source
Medline
License
Unknown

Abstract

CP-93,393 is a drug candidate at Pfizer. Flow-injection analysis-mass spectrometry (FIA-MS) was used to monitor reaction completion for CP-93,393 reaction mixtures. FIA-MS provides essentially instantaneous results, is relatively simple to operate, and is a universal system that can be used to monitor any reaction as long as the product has a molecular weight that differs from the molecular weights of the reactants. The mass spectrometer for these studies employed atmospheric pressure chemical ionization. Samples were introduced into the mass spectrometer with a flowing stream of solvent.

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