Monitoring CP-93,393 reaction mixtures by flow-injection analysis-mass spectrometry.
- Published Article
- Publication Date
Jun 01, 1996
CP-93,393 is a drug candidate at Pfizer. Flow-injection analysis-mass spectrometry (FIA-MS) was used to monitor reaction completion for CP-93,393 reaction mixtures. FIA-MS provides essentially instantaneous results, is relatively simple to operate, and is a universal system that can be used to monitor any reaction as long as the product has a molecular weight that differs from the molecular weights of the reactants. The mass spectrometer for these studies employed atmospheric pressure chemical ionization. Samples were introduced into the mass spectrometer with a flowing stream of solvent.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/18966555