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Monitoring of biological responses of tumor cells after irradiation with 99mTc-MIBI--an in vitro study.

Authors
  • Xia, J
  • Wu, H
  • Zhao, M
  • Xianyu, Z
Type
Published Article
Journal
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao
Publication Date
Jan 01, 2001
Volume
21
Issue
2
Pages
152–155
Identifiers
PMID: 11523224
Source
Medline
License
Unknown

Abstract

To explore the possibility to employ 99mTc-MIBI to monitor biological response of tumor cells after irradiation and to observe the relation between the radiation doses and the uptake levels of 99mTc-MIBI in tumor cells, the cells were irradiated with a single dose of 2 Gy, 10 Gy and 20 Gy respectively. The uptake of 99mTc-MIBI in each dosage group was determined before and 24, 48, 72 h after irradiation respectively. Apoptosis index (AI), plating efficiency (PE) of tumor cells was simultaneously determined. There was a positive correlation between uptake levels of 99mTc-MIBI and AI(r = -0.91, P < 0.05). A negative correlation was noted between the uptake levels and PE (r = -0.86, P < 0.05). It is suggested that 99mTc-MIBI may be used as a tracer to monitor the change of viability state of tumor cells after being irradiated with different doses.

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