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Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens

Authors
  • Singla, Rajeev K.
  • Dubey, Ashok K.
Type
Published Article
Journal
Current Topics in Medicinal Chemistry
Publisher
Bentham Science Publishers
Publication Date
Nov 01, 2019
Volume
19
Issue
28
Pages
2567–2578
Identifiers
DOI: 10.2174/1568026619666191025154834
PMID: 31654510
PMCID: PMC7403689
Source
PubMed Central
Keywords
License
Green

Abstract

Background Biofilm is a critical virulence factor associated with the strains of Candida spp. pathogens as it confers significant resistance to the pathogen against antifungal drugs. Methods A systematic review of the literature was undertaken by focusing on natural products, which have been reported to inhibit biofilms produced by Candida spp. The databases explored were from PubMed and Google Scholar. The abstracts and full text of the manuscripts from the literature were analyzed and included if found significant. Results Medicinal plants from the order Lamiales, Apiales, Asterales, Myrtales, Sapindales, Acorales, Poales and Laurales were reported to inhibit the biofilms formed by Candida spp. From the microbiological sources, lactobacilli, Streptomyces chrestomyceticus and Streptococcus thermophilus B had shown the strong biofilm inhibition potential. Further, the diverse nature of the compounds from classes like terpenoids, phenylpropanoid, alkaloids, flavonoids, polyphenol, naphthoquinone and saponin was found to be significant in inhibiting the biofilm of Candida spp. Conclusion: Natural products from both plant and microbial origins have proven themselves as a goldmine for isolating the potential biofilm inhibitors with a specific or multi-locus mechanism of action. Structural and functional characterization of the bioactive molecules from active extracts should be the next line of approach along with the thorough exploration of the mechanism of action for the already identified bioactive molecules.

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