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Molecularly targeted agents as radiosensitizers in cancer therapy--focus on prostate cancer.

Authors
  • Alcorn, Sara1
  • Walker, Amanda J
  • Gandhi, Nishant
  • Narang, Amol
  • Wild, Aaron T
  • Hales, Russell K
  • Herman, Joseph M
  • Song, Danny Y
  • Deweese, Theodore L
  • Antonarakis, Emmanuel S
  • Tran, Phuoc T
  • 1 Department of Radiation Oncology and Molecular Radiation Sciences, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
Jul 16, 2013
Volume
14
Issue
7
Pages
14800–14832
Identifiers
DOI: 10.3390/ijms140714800
PMID: 23863691
Source
Medline
License
Unknown

Abstract

As our understanding of the molecular pathways driving tumorigenesis improves and more druggable targets are identified, we have witnessed a concomitant increase in the development and production of novel molecularly targeted agents. Radiotherapy is commonly used in the treatment of various malignancies with a prominent role in the care of prostate cancer patients, and efforts to improve the therapeutic ratio of radiation by technologic and pharmacologic means have led to important advances in cancer care. One promising approach is to combine molecularly targeted systemic agents with radiotherapy to improve tumor response rates and likelihood of durable control. This review first explores the limitations of preclinical studies as well as barriers to successful implementation of clinical trials with radiosensitizers. Special considerations related to and recommendations for the design of preclinical studies and clinical trials involving molecularly targeted agents combined with radiotherapy are provided. We then apply these concepts by reviewing a representative set of targeted therapies that show promise as radiosensitizers in the treatment of prostate cancer.

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