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Molecular targeted therapy: novel therapeutic approach for head and neck cancer.

Authors
  • Shrivastava, Swatantra1
  • Nagi, Ravleen2
  • Sharma, Saurabh3
  • Rasul Sanadi, Sajid Ahmed4
  • Dafallah, Elbadri Taha4
  • Ragit, Akshay5
  • 1 Department of Oral Medicine & Radiology, New Horizon Dental College & Research Institute, Bilaspur, Chhattisgarh, India. , (India)
  • 2 Department of Oral Medicine & Radiology, Swami Devi Dyal Hospital and Dental College, Panchkula, Haryana 134003, India. , (India)
  • 3 Sai Care Hospital, Janjgir-Champa, Chhattisgarh 495671, India. , (India)
  • 4 King Abdullah Medical City, Makkah 23955, Saudi Arabia. , (Saudi Arabia)
  • 5 Department of Oral & Maxillofacial Surgery, New Horizon Dental College & Research Institute, Bilaspur, Chhattisgarh 495001, India. , (India)
Type
Published Article
Journal
Therapeutic Delivery
Publisher
"Future Science, LTD"
Publication Date
Oct 01, 2020
Volume
11
Issue
10
Pages
637–651
Identifiers
DOI: 10.4155/tde-2020-0028
PMID: 32777985
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cancer is a major public health burden worldwide, affecting millions of people each year. One of the major hallmarks of cancer is rapid growth and progression by evasion of host immune responses. Tumor resistance to conventional anticancer drugs by several mechanisms, such as drug inactivation, efflux pumps and enhanced toxicity to normal cells decreases their clinical efficacy. These limitations resulted in the development of new targeted agents, such as monoclonal antibodies and small molecule inhibitors that have high tumor specificity. This paper discusses the therapeutic applications of novel molecular targeted agents and immunotherapy as an alternative treatment option for head and neck cancers, as well as provides insight into future therapeutic approaches for advanced head and neck cancers.

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