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Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.

Authors
  • Zhang, Wei1
  • Du, Rong-Hui2
  • Li, Bei1
  • Zheng, Xiao-Shuang1
  • Yang, Xing-Lou1
  • Hu, Ben1
  • Wang, Yan-Yi1
  • Xiao, Geng-Fu1
  • Yan, Bing1
  • Shi, Zheng-Li1
  • Zhou, Peng1
  • 1 CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People's Republic of China. , (China)
  • 2 Wuhan Pulmonary Hospital, Wuhan, People's Republic of China. , (China)
Type
Published Article
Journal
Emerging microbes & infections
Publication Date
Jan 01, 2020
Volume
9
Issue
1
Pages
386–389
Identifiers
DOI: 10.1080/22221751.2020.1729071
PMID: 32065057
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral-fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral-fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes.

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