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Molecular profiling of breast cancer: portraits but not physiognomy.

Authors
  • Brenton, J D
  • Aparicio, S A
  • Caldas, C
Type
Published Article
Journal
Breast Cancer Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2001
Volume
3
Issue
2
Pages
77–80
Identifiers
PMID: 11250749
Source
Medline
License
Unknown

Abstract

Breast cancers differ in response to treatment and may have a divergent clinical course despite having a similar histopathological appearance. New technology using DNA microarrays provides a systematic method to identify key markers for prognosis and treatment response by profiling thousands of genes expressed in a single cancer. Microarray profiling of 38 invasive breast cancers now confirms striking molecular differences between ductal carcinoma specimens and suggests a new classification for oestrogen-receptor negative breast cancer. Future approaches will need to include methods for high-throughput clinical validation and the ability to analyze microscopic samples.

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