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The Molecular Physiology and Toxicology of Inward Rectifier Potassium Channels in Insects

Authors
  • Piermarini, Peter M.
  • Denton, Jerod S.
  • Swale, Daniel R.
Type
Published Article
Publisher
Annual Reviews
Publication Date
Jan 07, 2022
Volume
67
Pages
125–142
Identifiers
DOI: 10.1146/annurev-ento-062121-063338
Source
Annual Reviews
Keywords
License
Yellow

Abstract

Inward rectifier K+ (Kir) channels have been studied extensively in mammals, where they play critical roles in health and disease. In insects, Kir channels have recently been found to be key regulators of diverse physiological processes in several tissues. The importance of Kir channels in insects has positioned them to serve as emerging targets for the development of insecticides with novel modes of action. In this article, we provide the first comprehensive review of insect Kir channels, highlighting the rapid progress made in understanding their molecular biology, physiological roles, pharmacology, and toxicology. In addition, we highlight key gaps in our knowledge and suggest directions for future research to advance our understanding of Kir channels and their roles in insect physiology. Further knowledge of their functional roles will also facilitate their exploitation as targets for controlling arthropod pests and vectors of economic, medical, and/or veterinary relevance.

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