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Molecular pathways involved in the improvement of non-alcoholic fatty liver disease.

Authors
  • Paz-Filho, Gilberto
  • Mastronardi, Claudio Alberto
  • Parker, Brian J
  • Khan, Ainy
  • Inserra, Antonio
  • Matthaei, Klaus I
  • Ehrhart-Bornstein, Monika
  • Bornstein, Stefan
  • Wong, Ma-Li
  • Licinio, Julio
Type
Published Article
Journal
Journal of Molecular Endocrinology
Publisher
Bioscientifica
Publication Date
Jan 01, 2013
Volume
51
Issue
1
Pages
167–179
Identifiers
DOI: 10.1530/JME-13-0072
PMID: 23718963
Source
Medline
Keywords
License
Unknown

Abstract

wild-type eWAT transplantation into Lep(ob/ob) mice led to improvements in metabolism, body weight, and liver injury, possibly attributed to the production of leptin by the transplanted eWAT. These improvements were accompanied by the differential expression of novel pathways. The causal relationship between GABP downregulation and NAFLD improvement remains to be determined.

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