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Molecular mechanisms of viral oncogenesis in humans

Authors
  • Krump, Nathan A.1
  • You, Jianxin1
  • 1 University of Pennsylvania, Department of Microbiology, Perelman School of Medicine, Philadelphia, PA, USA , Philadelphia (United States)
Type
Published Article
Journal
Nature Reviews Microbiology
Publisher
Springer Nature
Publication Date
Aug 24, 2018
Volume
16
Issue
11
Pages
684–698
Identifiers
DOI: 10.1038/s41579-018-0064-6
Source
Springer Nature
License
Yellow

Abstract

Viral infection is a major contributor to the global cancer burden. In this Review, Krump and You explore the molecular mechanisms of viral oncogenesis in humans. They highlight how viral manipulation of host cellular signalling, DNA damage responses, immunity and microRNA targets promotes the initiation and development of cancer.

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