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[Molecular mechanisms of globin gene regulation and disregulation].

Authors
Type
Published Article
Journal
Nihon rinsho. Japanese journal of clinical medicine
Publication Date
Volume
54
Issue
9
Pages
2311–2319
Identifiers
PMID: 8890556
Source
Medline
License
Unknown

Abstract

Human globin genes are expressed in tissue and developmental stage specific manners. Various experiments including expression studies using the transgenic mouse system have been done to elucidate molecular mechanisms of globin gene regulation. Cis-elements and transcription factors, especially erythroid specific and stage specific factors, involved in proper globin gene regulation are summarized. A model of Hb switching is discussed in terms of the interaction of LCR with each globin gene region. Molecular mechanisms deteriorating or enhancing transcription of the globin genes in diseases such as thalassemia and HPFH, are also mentioned.

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