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Molecular mapping of epitopes for interaction of HIV-1 as well as natural ligands with the chemokine receptors, CCR5 and CXCR4.

Authors
  • Antonsson, Liselotte
  • Boketoft, Ake
  • Garzino-Demo, Alfredo
  • Olde, Björn
  • Owman, Christer
Type
Published Article
Journal
AIDS
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Dec 05, 2003
Volume
17
Issue
18
Pages
2571–2579
Identifiers
PMID: 14685051
Source
Medline
License
Unknown

Abstract

This study, for the first time monitoring CCR5 and CXCR4 ligand activation and HIV-1 interaction concomitantly, indicates that ligands and virus use different receptor epitopes which, in turn, vary between the two receptors. One particular chimera (FC-4b), having its junctional region close to the conserved cysteine in ECL2, functioned as coreceptor for both HIV-1BaL and HIV-1IIIB, but was not activated with RANTES or SDF-1beta. The results provide a basis for tailoring drugs that block viral entry through the two major coreceptors without interfering with their physiological function.

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