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Molecular Machines for Transport, Catalysis and Pumping

Authors
  • Shield, Jack
Publication Date
Feb 21, 2022
Source
Manchester eScholar
Keywords
Language
English
License
Unknown
External links

Abstract

Molecular machines are used in nature to carry out a wide range of sophisticated functions. These biological machines are remarkable in their efficiency and specificity but with this comes a great deal of complexity. As a result, precise analysis of their mode of operation becomes difficult to decipher. As synthetic chemists, we are able to design and construct molecules using a vast toolbox of chemical transformations. This thesis demonstrates the range of functions artificial molecular machines can be designed to perform. Firstly, a molecular transporter than can selectively move a cargo between four sites by judicious control of stimuli. Secondly, a mechanically chiral catenane-based structure that performs allosterically controlled asymmetric catalysis. Finally, a daisy chain polymer based on a molecular pump system that translates molecular motion across length scales to alter its macroscopic physical properties with sequential additions of acid and base.

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