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Molecular machinery mediating vesicle budding, docking and fusion.

Authors
  • Söllner, T H
  • Rothman, J E
Type
Published Article
Journal
Experientia
Publication Date
Dec 15, 1996
Volume
52
Issue
12
Pages
1021–1025
Identifiers
PMID: 8988241
Source
Medline
License
Unknown

Abstract

A general machinery buds and fuses transport vesicles which connect intracellular compartments with each other and allow communication with the extracellular environment. Cytoplasmic coat proteins deform membranes to bud vesicles and interact directly or indirectly with cargo molecules. Compartment-specific SNAREs (SNAP receptors) on vesicles and target membranes dock vesicles and provide a scaffolding for the general fusion machinery to initiate lipid bilayer fusion.

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