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Molecular Inverse Comorbidity between Alzheimer’s Disease and Lung Cancer: New Insights from Matrix Factorization

Authors
  • greco, alessandro
  • valle, jon sanchez
  • pancaldi, vera
  • baudot, anaïs
  • barillot, emmanuel
  • caselle, michele
  • valencia, alfonso
  • zinovyev, andrei
  • cantini, laura
Publication Date
Jun 26, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

LC inverse comorbidity as a case study, we highlight multiple molecular mechanisms, among which we confirm the involvement of processes related to the immune system and mitochondrial metabolism. We then distinguish mechanisms specific to LC from those shared with other cancers through a pan-cancer analysis. Additionally, new candidate molecular players, such as estrogen receptor (ER), cadherin 1 (CDH1) and histone deacetylase (HDAC), are pinpointed as factors that might underlie the inverse relationship, opening the way to new investigations. Finally, some lung cancer subtype-specific factors are also detected, also suggesting the existence of heterogeneity across patients in the context of inverse comorbidity.

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