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The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response

Authors
  • Coldbeck-Shackley, Rosa C.
  • Eyre, Nicholas S.
  • Beard, Michael R.
Type
Published Article
Journal
Vaccines
Publisher
MDPI
Publication Date
Sep 14, 2020
Volume
8
Issue
3
Identifiers
DOI: 10.3390/vaccines8030530
PMID: 32937990
PMCID: PMC7565347
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Green

Abstract

Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccination strategies. Type-I interferon (IFN) responses are important in clearing viral infection and for generating efficient adaptive immune responses towards infection and vaccination. However, ZIKV and DENV have evolved multiple molecular mechanisms to evade type-I IFN production. This review covers the molecular interactions, from detection to evasion, of these viruses with the type-I IFN response. Additionally, we discuss how this knowledge can be exploited to improve the design of new vaccine strategies.

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