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Molecular genetics in the pathology and diagnosis of retinoblastoma.

Authors
  • Gennett, I N
  • Cavenee, W K
Type
Published Article
Journal
Brain pathology (Zurich, Switzerland)
Publication Date
Sep 01, 1990
Volume
1
Issue
1
Pages
25–32
Identifiers
PMID: 1669690
Source
Medline
License
Unknown

Abstract

Retinoblastoma, the most common intraocular malignancy of children, has served as an important paradigm for understanding the events involved in neoplastic transformation. Much of the contemporary molecular description of human cancers stems directly from experimental approaches first developed to study this childhood tumour. This analytical methodology has demonstrated a major role for heritable predisposition in tumourigenesis, provided evidence for tissue pleiotropy of cancer genes, and revealed a more precise estimation of the number, activity, and location of other tumour suppressor loci.

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