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Molecular and Genetic Predictors of Breast-to-Brain Metastasis: Review and Case Presentation.

Authors
  • Medress, Zachary1
  • Hayden Gephart, Melanie1
  • 1 Department of Neurosurgery, Stanford University.
Type
Published Article
Journal
Cureus
Publisher
Cureus, Inc.
Publication Date
Jan 01, 2015
Volume
7
Issue
1
Identifiers
DOI: 10.7759/cureus.246
PMID: 26180670
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Brain metastases are the most common intracranial malignancy, and breast cancer is the second most common cancer to metastasize to the brain. Intracranial disease is a late manifestation of breast cancer with few effective treatment options, affecting 15-50% of breast cancer patients, depending upon molecular subtype. In this review article, we describe the genetic, molecular, and metabolic changes in breast cancer cells that facilitate breast to brain metastasis. We believe that advances in the understanding of breast to brain metastasis pathogenesis will lead to targeted molecular therapies and to improvements in the ability to prospectively identify patients at increased risk for developing intracranial disease.

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