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[Molecular and genetic background of sudden cardiac death].

Authors
  • Simkó, József
  • Szabó, Zoltán
  • Barta, Kitti
  • Ujvárosi, Dóra
  • Nánási, Péter
  • Lőrincz, István
Type
Published Article
Journal
Orvosi hetilap
Publication Date
Dec 16, 2012
Volume
153
Issue
50
Pages
1967–1983
Identifiers
DOI: 10.1556/OH.2012.29498
PMID: 23220363
Source
Medline
License
Unknown

Abstract

Despite recent findings on the functional, structural and genetic background of sudden cardiac death, the incidence is still relatively high in the entire population. A thorough knowledge on susceptibility, as well as pathophysiology behind the development of malignant arrhythmias will help us to identify individuals at risk and prevent sudden cardiac death. This article presents a review of the current literature on the role of altered intracellular Ca2+ handling, acute myocardial ischaemia, cardiac autonomic innervation, renin-angiotensin-aldosterone system, monogenic and complex heritability in the pathogenesis of sudden cardiac death.

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