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Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity.

Authors
  • Carr, Daniel F
  • Alfirevic, Ana
  • Tugwood, Jonathan D
  • Barratt, Bryan J
  • Sherwood, James
  • Smith, John
  • Pirmohamed, Munir
  • Park, B Kevin
Type
Published Article
Journal
Pharmacogenetics and Genomics
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Nov 01, 2007
Volume
17
Issue
11
Pages
961–972
Identifiers
PMID: 18075466
Source
Medline
License
Unknown

Abstract

The IL6 genotype may act as a predisposing factor for tacrine transaminitis. This, however, requires further confirmatory functional studies. The role of acute dosing rodent models in identifying candidate genes associated with drug-induced liver injury in man deserves further study.

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