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Molecular form and function of the cytokinetic ring.

Authors
  • Mangione, MariaSanta C1
  • Gould, Kathleen L2
  • 1 Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
  • 2 Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA [email protected]
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Jun 17, 2019
Volume
132
Issue
12
Identifiers
DOI: 10.1242/jcs.226928
PMID: 31209062
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Animal cells, amoebas and yeast divide using a force-generating, actin- and myosin-based contractile ring or 'cytokinetic ring' (CR). Despite intensive research, questions remain about the spatial organization of CR components, the mechanism by which the CR generates force, and how other cellular processes are coordinated with the CR for successful membrane ingression and ultimate cell separation. This Review highlights new findings about the spatial relationship of the CR to the plasma membrane and the arrangement of molecules within the CR from studies using advanced microscopy techniques, as well as mechanistic information obtained from in vitro approaches. We also consider advances in understanding coordinated cellular processes that impact the architecture and function of the CR. © 2019. Published by The Company of Biologists Ltd.

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