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Molecular features of sexual steroids on cartilage and bone

Authors
  • WOLFF, Roberta Bastos
  • GOMES, Regina Celia Teixeira
  • VERNA, Carina
  • CRISTOFANI MAIORAL, Gabriela Carolina C....
  • RAMPAZO, Thais Cristina
  • SIMÕES, Ricardo dos Santos
  • BARACAT, Edmund Chada
  • SOARES JUNIOR, Jose Maria
Publication Date
Aug 02, 2013
Source
Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP)
Keywords
Language
Portuguese
License
Unknown
External links

Abstract

In Brazil, the increase in the reported cases of degenerative diseases of articular cartilage is 20% per year, meaning that 200,000 Brazilians develop degenerative joint diseases every year, which have a negative impact on bone mass. This study shows evidence that hormone production of sexual steroids (estrogens, progestogens, and androgens) have an influence on cartilage quality, as well as on bone mass. Therefore, this review aimed to analyze literature data on the molecular and genic action of sexual steroids on hyaline cartilage and bone physiology, as well as osteoarthritis interference on the quality of these structures.

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